#Malvern zetasizer spectrometer software#
From the ground up, Aeris has been designed for maximum uptime. Uptime of the analytical equipment is therefore key. By allowing users to fully scope protein behavior within a formulation the Zetasizer Helix provides insight at the molecular level as to which variables trigger, for example, oligomerization and aggregation, supporting a QbD approach.įind out more about how the Zetasizer Helix can help with protein characterization and the application of QbD within biopharmaceutical development at Nano ZS90 for particle size and zeta potential measurements - Affordable molecular / particle size and zeta potential analyzer.Īn entry level system for the measurement of particle size and molecular size at a 90 degree scattering angle using Dynamic Light Scattering, also with the ability to measure zeta potential and electrophoretic mobility using Laser Doppler Microelectrophoresis, and molecular weight using Static Light Scattering. Fast and reliable feedback into the process is paramount for producing good-quality cement efficiently. A key priority for the industry is obtaining a greater understanding and control over the formulation process, a need exacerbated by the increasing adoption of QbD. The Zetasizer Helix is the latest commercialized product to emerge from Malvern’s Bioscience Development Initiative (BDI), a collaborative research program dedicated to providing solutions to the evolving needs of the biopharmaceutical industry. Parameters measured include: secondary and tertiary protein structure melting temperature onset temperature of aggregation and transition enthalpy values as well as aggregation propensity and protein solubility. The combination of dynamic light scattering with Raman spectroscopy characterizes a wealth of chemical, structural, and physical parameters of biotherapeutic proteins under formulation conditions - at high concentrations up to 100 mg/ml and using a wide range of buffers and excipients. Raman spectroscopy delivers information on protein unfolding by monitoring the variations in molecular vibrations that result from changes in secondary and tertiary protein structure. Such detailed information supports both the effective application of Quality by Design and the efficient development of biosimilars. The combination of DLS and Raman spectroscopy allows measurement of protein size and structure from a single small volume sample, providing unique insight into protein folding, unfolding, aggregation, agglomeration and oligomerization. Raman spectroscopy enables monitoring of the changes in secondary and tertiary protein structure. This new system combines industry-leading Zetasizer dynamic light scattering (DLS) technology, for sizing of proteins and other biomolecules, with Raman spectroscopy. The new Zetasizer Helix from Malvern Instruments is a powerful tool for early stage biopharmaceutical development that enables the detailed study of mechanisms of protein aggregation.
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